Workshop
Online
Workshop RedIF 2021

July 6th to 9th, 2021 | Online

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The objective of this course is to introduce professionals and researchers linked to the pharmaceutical sector to population analysis using nonlinear models with mixed effects, emphasizing the interpretation and evaluation of reports and results, as well as the application of the resulting information in the regulatory, industrial and clinical area.

About the event
Date: daily from July 6th to 9th, 2021

Time: 1:00 p.m. to 3:30 p.m. (GMT-3).

Language: Portuguese and Spanish exhibition, slides in English

InEvent Plataform: subscribers will receive a link to access

Limited number of participants

Instructors: Bibiana Verlindo de Araújo (UFRGS/Brazil), Francine Azeredo (UFBA/Brazil), Iñaki F. Trocóniz (UNAV/Spain), Manuel Ibarra (UdelaR/Uruguay), Natália de Moraes (UNESP/Brazil), Victor Mangas Sanjuán (UV/Spain) 

Duration: 10 h

Investment: R$ 50

 Registration begins June 14th until 30th

Check the program and schedule for this event
 

Day 1

  1. Introductory lecture: overview of pharmacometrics, evolution and applications. Iñaki F. Trocóniz 

  2. A quantitative vision on biopharmaceutics, pharmacokinetics, pharmacodynamics & disease progression. Bibiana Verlindo de Araújo

Day 2

  1. Population analysis: concepts & nomenclature. Francine Azeredo

  2. Covariate analysis. Manuel Ibarra

Day 3

  1. Model evaluation. Bibiana Verlindo de Araújo and Francine Azeredo

  2. Reporting pharmacometric analyses.  Iñaki F. Trocóniz

Day 4

  1. Application of pharmacometrics to guide the drug approval and labeling process. Victor Mangas Sanjuán 

  2. Applications in precision dosing. Natália de Moraes and Manuel Ibarra

Instructors
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Dr. Bibiana Verlindo de Araujo

UFRGS/Brazil

Dr. Bibiana Verlindo de Araujo is Professor of Pharmacokinetics and Clinical Pharmacokinetics at the Federal University of Rio Grande do Sul, where she teaches in the Faculty of Pharmacy and in the Graduate Program of Pharmaceutical Sciences.  She has a Pharmacy Bachelor’s Degree from the Federal University of Rio Grande do Sul, Master Science and Ph.D. degrees in Pharmaceutical Sciences from the same University. In 2009 she received an Honorable Mention by her Doctoral Thesis from CAPES. Her researches are focused in Pharmacokinetic/Pharmacodynamic modeling of antifungals, antimalarials and antidiabetics drugs, pharmacokinetics evaluation of new compounds and drug-loaded nanoparticles and microdialysis. In 2012 she has working in the University of Florida, improving her skills in population pharmacokinetics in the Departament of Pharmaceutics. Up to now she was advisor of 05 Master of Science Thesis, 03 Doctoral Thesis and more than 30 undergraduate students.  The results of her research were published in different indexed journal such as Antimicrobial Agents and Chemotherapy, European Journal of Pharmaceutical Sciences, International Journal of Antimicrobial Agents and Biomedical Chromatography, with more than 100 abstracts presented at Conferences and Congress.

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Dr. Iñaki F. Trocóniz

UNAV/Spain

Dr. Iñaki F. Trocóniz is Professor of Biopharmaceutics at the University of Navarra, Pamplona (Spain). Currently he is leading the research group in Pharmacometrics and Systems Pharmacology covering a broad spectrum of modelling aspects in oncology, gene therapy, auto-immune diseases and pain. He has published over one hundred fifty articles in peer reviewed journals, was awarded by the EUFEPS with the Giorgio Segré prize in pharmacokinetics/pharmacodynamics, and is the current Pharmacometrics section editor of Pharmaceutical Research.

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Dr. Natália Valadares de Moraes

UNESP/Brazil

Dr. Natália Valadares de Moraes is an Assistant Professor at São Paulo State University (UNESP), in the Department of Drugs and Medicines, in Brazil. Her experience in Pharmacokinetics, Clinical Pharmacology and Pharmacometrics is documented by the 30 published papers in renowned peer-reviewed journals. She has been actively training PharmD students, PhD students and post-doctoral research associates in precision dosing, clinical pharmacology, toxicology, pharmacokinetics and pharmacometrics. Currently she is part of the advisory board in both graduate programs of Toxicology at University of São Paulo and Pharmaceutical Sciences at São Paulo State University. In 2020, she founded the Center of Pharmacometrics and Toxicological Analysis (CFAT) at UNESP. As part of her activities at CFAT, she serves as a consultant for two pharmaceutical companies to set health-based exposure limits for pharmaceutical active ingredients. 

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Dr. Francine Johansson Azeredo

UFBA/Brazil

Dr. Francine Johansson Azeredo is a Professor of pharmacokinetics at the Federal University of Bahia, where she coordinates the Pharmacokinetics and Pharmacometrics Lab and is Head of the Department of Medicines. She holds a PharmD from the Federal University of Rio Grande do Sul and a Ph.D. in Pharmaceutical Sciences from the same university. She is an advisor on the Graduate Program at the Federal University of Bahia and has published and revised articles in different journals. Her research focuses on pharmacokinetic analysis, PK/PD modeling, microdialysis, and clinical population pharmacokinetics.

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Dr. Manuel Ibarra

UdelaR/Uruguay

Dr. Manuel Ibarra is an Associate Professor of the Pharmaceutical Sciences Department at the School of Chemistry – Universidad de la República (UdelaR) of Uruguay, where he currently is the Analytical and Biostatistics Supervisor of the University’s Bioavailability and Bioequivalence Centre for Medicine Evaluation (CEBIOBE). He studied Pharmaceutical Chemistry at the School of Chemistry obtaining his Master’s degree in 2009. In 2010 he started the Chemistry Postgraduate program at UdelaR, with focus on the evaluation of sex-related differences in drug pharmacokinetics and bioequivalence. He was awarded with the Ph.D. degree in 2014. During his Ph.D. studies, while doing a short-term scholarship at the College of Pharmacy of the University of Florida (Pharmaceutics Department), he got involved with the science of pharmacometrics. Since then, his research focus has been exploring and developing pharmacometric models in basic and applied pharmacological research, aiming to the understanding of specific pharmacokinetic processes and translational applications such as model-informed precision dosing, virtual & model-based bioequivalence, among other applications. He contributes to the pharmacometric analysis of data generated at CEBIOBE and the Therapeutic Drug Monitoring Unit of the University Hospital and supervises the work of PhD and grade students.  Some of his work includes the local and regional active promotion and dissemination of pharmacometrics, through the organization of scientific meetings and educational instances. He is a co-founder and the Uruguayan Coordinator of the Iberoamerican Pharmacometrics Network (RedIF, redifar.org).

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Dr. Victor Mangas Sanjuán

UV/Spain

Dr. Victor Mangas Sanjuán has a degree in Pharmacy from the Miguel Hernández University of Elche in 2009. He continued his postgraduate studies at the University of Valencia, where in 2010 he obtained a Master's degree. In 2014, he obtained his Ph.D. from the University of Valencia. In 2016, he carried out his post-doctoral activity at the University of Navarra, under the supervision of Prof. Iñaki Trocóniz. He has made research stays at the University of Leiden, the University of Navarra, and the University College of London. Since 2017 he has been an Assistant Professor at the University of Valencia. His research focuses on the area of pharmacometrics, through the development of population PK / PD models, PBPK models, and methodologies for the comparison of dissolution profiles. He is a member of the Modeling and Simulation Working Party and the Pharmacokinetic Working Party of the EMA.